Mechanism of Resistance Development in <i>E. coli</i> against TCAT, a Trimethoprim-Based Photoswitchable Antibiotic

• Main Authors: Anna I. Lauxen (Author), Piermichele Kobauri (Author), Michael Wegener (Author), Mickel J. Hansen (Author), Nicole S. Galenkamp (Author), Giovanni Maglia (Author), Wiktor Szymanski (Author), Ben L. Feringa (Author), Oscar P. Kuipers (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During the last decades, a continuous rise of multi-drug resistant pathogens has threatened antibiotic efficacy. To tackle this key challenge, novel antimicrobial therapies are needed with increased specificity for the site of infection. Photopharmacology could enable such specificity by allowing fo...