A humanized monoclonal antibody targeting CD39 with novel mechanism for cancer treatment

• Main Authors: Zheng Wei (Author), Fang Ren (Author), Shiyong Gong (Author), Beilei Shi (Author), Kedong Ouyang (Author), Chengbin Wu (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ATP-adenosine signal axis plays an import role in tumor immune regulation. ATP released by tumor cells can promote antitumor immunity, and adenosine can suppress the immune response. CD39, also known as Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), can hydrolyze ATP into ADP and AMP, then...