Lipid-lowering interventions targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): an emerging chapter in lipid-lowering therapy

• Main Authors: Constantine E Kosmas (Author), Eddy DeJesus (Author), Rosmery Morcelo (Author), Frank Garcia (Author), Peter D Montan (Author), Eliscer Guzman (Author)
• Formato: Livro
• Publicado em: BioExcel Publishing Ltd, 2017-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that is mainly expressed in the liver but can also be found in the intestine and kidneys. PCSK9 promotes the degradation of low density lipoprotein receptors (LDLR) by reducing their recycling and targeting the receptors for...