Detection of Intranasally Delivered Bone Marrow-Derived Mesenchymal Stromal Cells in the Lesioned Mouse Brain: A Cautionary Report

• Main Authors: Elena H. Chartoff (Author), Diane Damez-Werno (Author), Kai C. Sonntag (Author), Linda Hassinger (Author), Daniel E. Kaufmann (Author), Jesse Peterson (Author), Donna McPhie (Author), Anne M. Cataldo (Author), Bruce M. Cohen (Author)
• Format: Book
• Published: Hindawi Limited, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone marrow-derived mesenchymal stromal cells (MSCs) hold promise for autologous treatment of neuropathologies. Intranasal delivery is relatively noninvasive and has recently been reported to result in transport of MSCs to the brain. However, the ability of MSCs to migrate from nasal passages to sit...