Synthesis and Antitumor Activity of (3-Hydroxyacrylato-O,O') Diammineplatinum(II)

• Main Authors: Yong-Zhi Shu (Author), Jun Lin (Author), Bao-Quan Zhu (Author), Quan-Hai Liu (Author), Bin Zhou (Author), Hai-Feng Hu (Author), Dian-Wen Ju (Author)
• Format: Book
• Published: Georg Thieme Verlag KG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As an indispensable part of cancer chemotherapy, platinum drugs still play an important role in cancer treatment. In this study, two platinum(II) complexes with Michael acceptor 3-hydroxyacrylic acid as the leaving group were synthesized from cis-diamminediiodo platinum(II) and 3-ethoxyacrylic acid....