Design and Synthesis of New Anthranyl Phenylhydrazides: Antileishmanial Activity and Structure-Activity Relationship

• Main Authors: Claudia do Carmo Maquiaveli (Author), Edson Roberto da Silva (Author), Barbara Hild de Jesus (Author), Caio Eduardo Oliveira Monteiro (Author), Tiago Rodrigues Navarro (Author), Luiz Octavio Pereira Branco (Author), Isabela Souza dos Santos (Author), Nanashara Figueiredo Reis (Author), Arieli Bernardo Portugal (Author), João Luiz Mendes Wanderley (Author), André Borges Farias (Author), Nelilma Correia Romeiro (Author), Evanoel Crizanto de Lima (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmaniasis is a neglected tropical disease affecting millions of people worldwide. A centenary approach to antimonial-based drugs was first initiated with the synthesis of urea stibamine by Upendranath Brahmachari in 1922. The need for new drug development led to resistance toward antimoniates. N...