Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity

• Main Authors: Hassan H. Fakih (Author), Qi Tang (Author), Ashley Summers (Author), Minwook Shin (Author), Julianna E. Buchwald (Author), Rosemary Gagnon (Author), Vignesh N. Hariharan (Author), Dimas Echeverria (Author), David A. Cooper (Author), Jonathan K. Watts (Author), Anastasia Khvorova (Author), Hanadi F. Sleiman (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although an increasing number of small interfering RNA (siRNA) therapies are reaching the market, the challenge of efficient extra-hepatic delivery continues to limit their full therapeutic potential. Drug delivery vehicles and hydrophobic conjugates are being used to overcome the delivery bottlenec...