Improvement of Targeted Chemotherapy of HER2-positive Ovarian Malignant Cell Line by ZHER2-Idarubicin Conjugate: An in vitro Study

• Main Authors: Lila Siavoshinia (Author), Mostafa Jamalan (Author), Majid Zeinali (Author), Aminollah Pourshohod (Author), Mahdie Koushki (Author), Bahman Moradipoodeh (Author), Ghorban Mohammadzadeh (Author)
• Format: Book
• Published: Iranian Society of Pathology, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background & objectives: Overexpression of human epidermal growth factor receptor 2 (HER2) causes cell transformation and development of various types of malignancies. Idarubicin is an effective anti-neoplastic drug but specific delivery of it to the targeted cells is still a great challenge. Af...