Integrative Ligand-Based Pharmacophore Modeling, Virtual Screening, and Molecular Docking Simulation Approaches Identified Potential Lead Compounds against Pancreatic Cancer by Targeting FAK1

• Main Authors: Mohammad Habibur Rahman Molla (Author), Mohammed Othman Aljahdali (Author), Md Afsar Ahmed Sumon (Author), Amer H. Asseri (Author), Hisham N. Altayb (Author), Md. Shafiqul Islam (Author), Ahad Amer Alsaiari (Author), F. A. Dain Md Opo (Author), Nushrat Jahan (Author), Foysal Ahammad (Author), Farhan Mohammad (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic cancer is a very deadly disease with a 5-year survival rate, making it one of the leading causes of cancer-related deaths globally. Focal adhesion kinase 1 (FAK1) is a ubiquitously expressed protein in pancreatic cancer. FAK, a tyrosine kinase that is overexpressed in cancer cells, is cru...