Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice

• Main Authors: Yoshiyuki Kasahara (Author), Yasufumi Sakakibara (Author), Takashi Hiratsuka (Author), Yuki Moriya (Author), Klaus‐Peter Lesch (Author), F. Scott Hall (Author), George R. Uhl (Author), Ichiro Sora (Author)
• Format: Book
• Published: Wiley, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aim Repeated psychostimulant drug treatment, including methamphetamine, in rodents readily produces behavioral sensitization, which reflects altered brain function caused by repeated drug exposure. Dendritic remodeling of medium spiny neurons in the nucleus accumbens is thought to be an ess...