Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue

• Main Authors: Kosuke Okada (Author), Katherine B. LeClair (Author), Yongzhao Zhang (Author), Yingxia Li (Author), Cafer Ozdemir (Author), Tibor I. Krisko (Author), Susan J. Hagen (Author), Rebecca A. Betensky (Author), Alexander S. Banks (Author), David E. Cohen (Author)
• Format: Book
• Published: Elsevier, 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Non-shivering thermogenesis in brown adipose tissue (BAT) plays a central role in energy homeostasis. Thioesterase superfamily member 1 (Them1), a BAT-enriched long chain fatty acyl-CoA thioesterase, is upregulated by cold and downregulated by warm ambient temperatures. Them1−/− mice exhi...