Agonist bias and agonist‐dependent antagonism at corticotrophin releasing factor receptors

• Main Authors: Zoe Tasma (Author), Peter Wills (Author), Debbie L. Hay (Author), Christopher S. Walker (Author)
• Format: Knjiga
• Izdano: Wiley, 2020-06-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract The corticotropin‐releasing factor (CRF) receptors represent potential drug targets for the treatment of anxiety, stress, and other disorders. However, it is not known if endogenous CRF receptor agonists display biased signaling, how effective CRF receptor antagonists are at blocking differ...