Dasatinib suppresses particulate-induced pyroptosis and acute lung inflammation

• Main Authors: Yixi Pan (Author), Kenta Ikoma (Author), Risa Matsui (Author), Akiyoshi Nakayama (Author), Naoki Takemura (Author), Tatsuya Saitoh (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Humans are constantly exposed to various industrial, environmental, and endogenous particulates that result in inflammatory diseases. After being engulfed by immune cells, viz. Macrophages, such particulates lead to phagolysosomal dysfunction, eventually inducing pyroptosis, a form of ce...