Local Investigators Significantly Overestimate Overall Response Rates Compared to Blinded Independent Central Reviews in Uncontrolled Oncology Trials: A Comprehensive Review of the Literature

Several drugs gained market authorization based on the demonstration of improved progression-free survival (PFS), adopted as a primary endpoint in Phase 3 clinical trials. In addition, an increasing number of drugs have been granted accelerated approval, and sometimes regular approval, by the main r...

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Main Authors: Cinzia Dello Russo (Author), Pierluigi Navarra (Author)
Format: Book
Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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