Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats

• Main Authors: Akiko Kawade (Author), Aya Yamamura (Author), Moe Fujiwara (Author), Saki Kobayashi (Author), Shiho Mori (Author), Chihiro Horii (Author), Akari Hiraku (Author), Sayo Suzumura (Author), Kikuo Tsukamoto (Author), Naoki Ohara (Author), Rubii Kondo (Author), Yoshiaki Suzuki (Author), Hisao Yamamura (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary arterial hypertension (PAH) is a rare, progressive, and fatal cardiovascular/lung disease. The incidence rate is affected by age. Monocrotaline (MCT, 60 mg/kg)-treated rats are widely used as an experimental PAH model. Here, we found that young rats died at a mean of 23.4 days after MCT in...