A Novel PBM for Nanomilling of Drugs in a Recirculating Wet Stirred Media Mill: Impacts of Batch Size, Flow Rate, and Back-Mixing

• 主要な著者: Hamidreza Heidari (著者), Nontawat Muanpaopong (著者), Gulenay Guner (著者), Helen F. Yao (著者), Donald J. Clancy (著者), Ecevit Bilgili (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2024-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

We examined the evolution of fenofibrate (FNB, drug) particle size distribution (PSD) during the production of nanosuspensions via wet stirred media milling (WSMM) with a cell-based population balance model (PBM). Our objective was to elucidate the potential impacts of batch size, suspension volumet...