Phase II study of intraperitoneal submicron particle paclitaxel (SPP) plus IV carboplatin and paclitaxel in patients with epithelial ovarian cancersurgery

• Main Authors: Sally Mullany (Author), David Scott Miller (Author), Katina Robison (Author), Kimberly Levinson (Author), Yi-Chun Lee (Author), S. Diane Yamada (Author), Joan Walker (Author), Maurie Markman (Author), Alyson Marin (Author), Peter Mast (Author), Gere diZerega (Author)
• Format: Book
• Published: Elsevier, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Submicron particles (~800 nm) of paclitaxel (SPP) contain 1-2 billion molecules of pure drug that release tumoricidal levels of paclitaxel over many weeks. This study compared two dose-levels of SPP instilled into the peritoneal cavity (IP) in 200 ml of saline post-cytoreductive surgery. Eligible pa...