Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

• Main Authors: Yingfeng Deng (Author), Zhao V. Wang (Author), Ruth Gordillo (Author), Yi Zhu (Author), Aktar Ali (Author), Chen Zhang (Author), Xiaoding Wang (Author), Mengle Shao (Author), Zhuzhen Zhang (Author), Puneeth Iyengar (Author), Rana K. Gupta (Author), Jay D. Horton (Author), Joseph A. Hill (Author), Philipp E. Scherer (Author)
• Format: Book
• Published: Elsevier, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The spliced transcription factor Xbp1 (Xbp1s), a transducer of the unfolded protein response (UPR), regulates lipolysis. Lipolysis is stimulated by fasting when uridine synthesis is also activated in adipocytes. Methods: Here we have examined the regulatory role Xbp1s in stimulation of ur...