Poly(Beta-Amino Ester) Nanoparticles Enable Nonviral Delivery of CRISPR-Cas9 Plasmids for Gene Knockout and Gene Deletion

Poly(Beta-Amino Ester) Nanoparticles Enable Nonviral Delivery of CRISPR-Cas9 Plasmids for Gene Knockout and Gene Deletion

The CRISPR-Cas9 system is a powerful gene-editing tool with wide-ranging applications, but the safe and efficient intracellular delivery of CRISPR components remains a challenge. In this study, we utilized biodegradable poly(beta-amino ester) nanoparticles to codeliver plasmid DNA encoding Cas9 and...

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Main Authors: Yuan Rui (Author), Mahita Varanasi (Author), Shanelle Mendes (Author), Hannah M. Yamagata (Author), David R. Wilson (Author), Jordan J. Green (Author)
Format: Book
Published: Elsevier, 2020-06-01T00:00:00Z.
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