Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport

• Main Authors: Astrid S. Kahnt (Author), Carlo Angioni (Author), Tamara Göbel (Author), Bettina Hofmann (Author), Jessica Roos (Author), Svenja D. Steinbrink (Author), Florian Rörsch (Author), Dominique Thomas (Author), Gerd Geisslinger (Author), Kai Zacharowski (Author), Sabine Grösch (Author), Dieter Steinhilber (Author), Thorsten J. Maier (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

5-Lipoxygenase (5-LO) is the key enzyme in the formation of pro-inflammatory leukotrienes (LT) which play an important role in a number of inflammatory diseases. Accordingly, 5-LO inhibitors are frequently used to study the role of 5-LO and LT in models of inflammation and cancer. Interestingly, the...