Novel reporter mouse models useful for evaluating in vivo gene editing and for optimization of methods of delivering genome editing tools

• Main Authors: Hiromi Miura (Author), Jurai Imafuku (Author), Aki Kurosaki (Author), Masahiro Sato (Author), Yongjie Ma (Author), Guisheng Zhang (Author), Akiko Mizutani (Author), Kenya Kamimura (Author), Channabasavaiah B. Gurumurthy (Author), Dexi Liu (Author), Masato Ohtsuka (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The clustered regularly interspersed palindromic repeats (CRISPR) system is a powerful genome-editing tool to modify genomes, virtually in any species. The CRISPR tool has now been utilized in many areas of medical research, including gene therapy. Although several proof-of-concept studies show the...