The m6A Methylation-Regulated AFF4 Promotes Self-Renewal of Bladder Cancer Stem Cells

• Main Authors: Qian Gao (Author), Jin Zheng (Author), Zegui Ni (Author), Pengli Sun (Author), Congcong Yang (Author), Maosheng Cheng (Author), Mingqing Wu (Author), Xiuhong Zhang (Author), Lin Yuan (Author), Yingyin Zhang (Author), Yang Li (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The dynamic N6-methyladenosine (m6A) modification of mRNA plays a role in regulating gene expression and determining cell fate. However, the functions of m6A mRNA modification in bladder cancer stem cells (BCSCs) have not been described. Here, we show that global RNA m6A abundance and the expression...