ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure

ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure

The widely expressed and poly-specific ABC transporters breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1) are co-localized at the blood-brain barrier (BBB) and have shown to limit the brain distribution of several clinically used ABCB1/ABCG2 substrate drugs. It is currently not kno...

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Main Authors: Myriam El Biali (Author), Rudolf Karch (Author), Cécile Philippe (Author), Helmuth Haslacher (Author), Nicolas Tournier (Author), Marcus Hacker (Author), Markus Zeitlinger (Author), Doreen Schmidl (Author), Oliver Langer (Author), Martin Bauer (Author)
Format: Book
Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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