Vagotomy Affects the Development of Oral Tolerance and Increases Susceptibility to Develop Colitis Independently of α-7 Nicotinic Receptor

• Main Authors: Martina Di Giovangiulio (Author), Goele Bosmans (Author), Elisa Meroni (Author), Nathalie Stakenborg (Author), Morgane Florens (Author), Giovanna Farro (Author), Pedro J Gomez-Pinilla (Author), Gianluca Matteoli (Author), Guy E Boeckxstaens (Author)
• Format: Book
• Published: BMC, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Vagotomy (VGX) increases the susceptibility to develop colitis suggesting a crucial role for the cholinergic anti-inflammatory pathway in the regulation of the immune responses. Since oral tolerance and the generation of regulatory T cells (Tregs) are crucial to preserve mucosal immune home...