Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells

• Main Authors: Allison Grenell (Author), Charandeep Singh (Author), Monisha Raju (Author), Alyson Wolk (Author), Sonal Dalvi (Author), Geeng-Fu Jang (Author), John S. Crabb (Author), Courtney E. Hershberger (Author), Kannan V. Manian (Author), Karen Hernandez (Author), John W. Crabb (Author), Ruchira Singh (Author), Jianhai Du (Author), Bela Anand-Apte (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Mutations in Tissue Inhibitor of Metalloproteinases 3 (TIMP3) cause Sorsby's Fundus Dystrophy (SFD), a dominantly inherited, rare form of macular degeneration that results in vision loss. TIMP3 is synthesized primarily by retinal pigment epithelial (RPE) cells, which constitute the...