Aurone derivatives as Vps34 inhibitors that modulate autophagy

• Main Authors: Guodong Li (Author), Joshua William Boyle (Author), Chung-Nga Ko (Author), Wu Zeng (Author), Vincent Kam Wai Wong (Author), Jian-Bo Wan (Author), Philip Wai Hong Chan (Author), Dik-Lung Ma (Author), Chung-Hang Leung (Author)
• Format: Book
• Published: Elsevier, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We report in this study the identification of a natural product-like antagonist (1a) of Vps34 as a potent autophagy modulator via structure-based virtual screening. Aurone derivative 1a strongly inhibited Vps34 activity in cell-free and cell-based assays. Significantly, 1a prevents autophagy in huma...