Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model

• Главные авторы: Tobias M. Huijink (Автор), Leonie H. Venema (Автор), Rene A. Posma (Автор), Nynke J. deVries (Автор), Andrie C. Westerkamp (Автор), Petra J. Ottens (Автор), Daan J. Touw (Автор), Maarten W. Nijsten (Автор), Henri G.D. Leuvenink (Автор)
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• Опубликовано: Wiley, 2021-01-01T00:00:00Z.
• Предметы: article
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Metformin may act renoprotective prior to kidney transplantation by reducing ischemia‐reperfusion injury (IRI). This study examined whether metformin preconditioning and postconditioning during ex vivo normothermic machine perfusion (NMP) of rat and porcine kidneys affect IRI. In the rat study, sali...