Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model

• Main Authors: Tobias M. Huijink (Author), Leonie H. Venema (Author), Rene A. Posma (Author), Nynke J. deVries (Author), Andrie C. Westerkamp (Author), Petra J. Ottens (Author), Daan J. Touw (Author), Maarten W. Nijsten (Author), Henri G.D. Leuvenink (Author)
• Format: Book
• Published: Wiley, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metformin may act renoprotective prior to kidney transplantation by reducing ischemia‐reperfusion injury (IRI). This study examined whether metformin preconditioning and postconditioning during ex vivo normothermic machine perfusion (NMP) of rat and porcine kidneys affect IRI. In the rat study, sali...