Pharmacological agents targeting drug-tolerant persister cells in cancer

• Main Authors: Yu-Chi Chen (Author), Krishne Gowda (Author), Shantu Amin (Author), Todd D. Schell (Author), Arun K. Sharma (Author), Gavin P. Robertson (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Current cancer therapy can be effective, but the development of drug resistant disease is the usual outcome. These drugs can eliminate most of the tumor burden but often fail to eliminate the rare, "Drug Tolerant Persister" (DTP) cell subpopulations in residual tumors, which can be referre...