Ex Vivo COL7A1 Correction for Recessive Dystrophic Epidermolysis Bullosa Using CRISPR/Cas9 and Homology-Directed Repair

• Egile Nagusiak: Araksya Izmiryan (Egilea), Clarisse Ganier (Egilea), Matteo Bovolenta (Egilea), Alain Schmitt (Egilea), Fulvio Mavilio (Egilea), Alain Hovnanian (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2018-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Recessive dystrophic epidermolysis bullosa is a rare and severe genetic skin disease resulting in blistering of the skin and mucosa. Recessive dystrophic epidermolysis bullosa (RDEB) is caused by a wide variety of mutations in COL7A1-encoding type VII collagen, which is essential for dermal-epiderma...