Modulation of Acid Sphingomyelinase in Melanoma Reprogrammes the Tumour Immune Microenvironment

• Main Authors: Emma Assi (Author), Davide Cervia (Author), Laura Bizzozero (Author), Annalisa Capobianco (Author), Sarah Pambianco (Author), Federica Morisi (Author), Clara De Palma (Author), Claudia Moscheni (Author), Paolo Pellegrino (Author), Emilio Clementi (Author), Cristiana Perrotta (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The inflammatory microenvironment induces tumours to acquire an aggressive and immunosuppressive behaviour. Since acid sphingomyelinase (A-SMase) downregulation in melanoma was shown to determine a malignant phenotype, we aimed here to elucidate the role of A-SMase in the regulation of tumour immuno...