N6-methyladenosine and its epitranscriptomic effects on hematopoietic stem cell regulation and leukemogenesis

• Main Authors: Kao-Jung Chang (Author), Li-Yang Shiau (Author), Shiuan-Chen Lin (Author), Han-Ping Cheong (Author), Ching-Yun Wang (Author), Chun Ma (Author), Yan-Wen Liang (Author), Yi-Ping Yang (Author), Po-Shen Ko (Author), Chih-Hung Hsu (Author), Shih-Hwa Chiou (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract N6-methyladenosine (m6A) RNA modification orchestrates cellular epitranscriptome through tuning the homeostasis of transcript stability, translation efficiency, and the transcript affinity toward RNA-binding proteins (RBPs). An aberrant m6A deposition on RNA can lead toward oncogenic expres...