N6-methyladenosine and its epitranscriptomic effects on hematopoietic stem cell regulation and leukemogenesis

• Egile Nagusiak: Kao-Jung Chang (Egilea), Li-Yang Shiau (Egilea), Shiuan-Chen Lin (Egilea), Han-Ping Cheong (Egilea), Ching-Yun Wang (Egilea), Chun Ma (Egilea), Yan-Wen Liang (Egilea), Yi-Ping Yang (Egilea), Po-Shen Ko (Egilea), Chih-Hung Hsu (Egilea), Shih-Hwa Chiou (Egilea)
• Formatua: Liburua
• Argitaratua: BMC, 2024-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract N6-methyladenosine (m6A) RNA modification orchestrates cellular epitranscriptome through tuning the homeostasis of transcript stability, translation efficiency, and the transcript affinity toward RNA-binding proteins (RBPs). An aberrant m6A deposition on RNA can lead toward oncogenic expres...