N6-methyladenosine and its epitranscriptomic effects on hematopoietic stem cell regulation and leukemogenesis

• मुख्य लेखकों: Kao-Jung Chang (लेखक), Li-Yang Shiau (लेखक), Shiuan-Chen Lin (लेखक), Han-Ping Cheong (लेखक), Ching-Yun Wang (लेखक), Chun Ma (लेखक), Yan-Wen Liang (लेखक), Yi-Ping Yang (लेखक), Po-Shen Ko (लेखक), Chih-Hung Hsu (लेखक), Shih-Hwa Chiou (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2024-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract N6-methyladenosine (m6A) RNA modification orchestrates cellular epitranscriptome through tuning the homeostasis of transcript stability, translation efficiency, and the transcript affinity toward RNA-binding proteins (RBPs). An aberrant m6A deposition on RNA can lead toward oncogenic expres...