Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect

• Main Authors: Kai-Hua Xue (Author), Yi-Fan Jiang (Author), Ji-Yu Bai (Author), Di-Ze Zhang (Author), Yu-Hang Chen (Author), Jian-Bin Ma (Author), Zhi-Jing Zhu (Author), Xinyang Wang (Author), Peng Guo (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTBackground Metabolic alteration drives renal cell carcinoma (RCC) development, while the impact of melatonin (MLT), a neurohormone secreted during darkness, on RCC cell growth and underlying mechanisms remains unclear.Methods We detected concentration of metabolites through metabolomic analy...