Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer

New series of thiazolyl-pyrazoline derivatives (7a-7d, 10a-10d and 13a-13f) have been synthesised and assessed for their potential EGFR and VEGFR-2 inhibitory activities. Compounds 10b and 10d exerted potent and selective inhibitory activity towards the two receptor tyrosine kinases; EGFR (IC50 = 40...

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Main Authors: Esraa A. Abdelsalam (Author), Amer Ali Abd El-Hafeez (Author), Wagdy M. Eldehna (Author), Mahmoud A. El Hassab (Author), Hala Mohamed M. Marzouk (Author), Mahmoud M. Elaasser (Author), Nageh A. Abou Taleb (Author), Kamilia M. Amin (Author), Hatem A. Abdel-Aziz (Author), Pradipta Ghosh (Author), Sherif F. Hammad (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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