Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer

• Main Authors: Esraa A. Abdelsalam (Author), Amer Ali Abd El-Hafeez (Author), Wagdy M. Eldehna (Author), Mahmoud A. El Hassab (Author), Hala Mohamed M. Marzouk (Author), Mahmoud M. Elaasser (Author), Nageh A. Abou Taleb (Author), Kamilia M. Amin (Author), Hatem A. Abdel-Aziz (Author), Pradipta Ghosh (Author), Sherif F. Hammad (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New series of thiazolyl-pyrazoline derivatives (7a-7d, 10a-10d and 13a-13f) have been synthesised and assessed for their potential EGFR and VEGFR-2 inhibitory activities. Compounds 10b and 10d exerted potent and selective inhibitory activity towards the two receptor tyrosine kinases; EGFR (IC50 = 40...