Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury

• Main Authors: Andrea Villar-Lorenzo (Author), Patricia Rada (Author), Esther Rey (Author), Patricia Marañón (Author), Ana I. Arroba (Author), Beatriz Santamaría (Author), Jorge Sáiz (Author), Francisco J. Rupérez (Author), Coral Barbas (Author), Carmelo García-Monzón (Author), Ángela M. Valverde (Author), Águeda González-Rodríguez (Author)
• Format: Book
• Published: The Company of Biologists, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Insulin receptor substrate 2 (IRS2) is a key downstream mediator of insulin and insulin-like growth factor 1 (IGF1) signalling pathways and plays a major role in liver metabolism. The aim of this study was to investigate whether IRS2 had an impact on the hepatic fibrotic process associated with chol...