Physical basis of the 'magnification rule' for standardized Immunohistochemical scoring of HER2 in breast and gastric cancer

• Main Authors: Andreas H. Scheel (Author), Frédérique Penault-Llorca (Author), Wedad Hanna (Author), Gustavo Baretton (Author), Peter Middel (Author), Judith Burchhardt (Author), Manfred Hofmann (Author), Bharat Jasani (Author), Josef Rüschoff (Author)
• Format: Book
• Published: BMC, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Detection of HER2/neu receptor overexpression and/or amplification is a prerequisite for efficient anti-HER2 treatment of breast and gastric carcinomas. Immunohistochemistry (IHC) of the HER2 protein is the most common screening test, thus precise and reproducible IHC-scoring is...