GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1

• Egile Nagusiak: Dandan Ma (Egilea), Wei Sun (Egilea), Cuicui Fu (Egilea), Kamran Nazmi (Egilea), Enno C. I. Veerman (Egilea), Richard T. Jaspers (Egilea), Jan G. M. Bolscher (Egilea), Floris J. Bikker (Egilea), Gang Wu (Egilea)
• Formatua: Liburua
• Argitaratua: Nature Publishing Group, 2022-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Human salivary histatin 1 (Hst1) exhibits a series of cell-activating properties, such as promoting cell spreading, migration, and metabolic activity. We recently have shown that fluorescently labeled Hst1 (F-Hst1) targets and activates mitochondria, presenting an important molecular mechan...