The Endothelial Tyrosine Phosphatase SHP-1 Plays an Important Role for Vascular Haemostasis in TNFα-Induced Inflammation In Vivo

• Main Authors: Elisabeth Koch (Author), Joachim Pircher (Author), Thomas Czermak (Author), Erik Gaitzsch (Author), Stefan Alig (Author), Hanna Mannell (Author), Markus Niemeyer (Author), Florian Krötz (Author), Markus Wörnle (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction. Inflammation and endothelium-derived superoxides are important pathomechanisms in atherothrombotic diseases. We could previously show that the tyrosine phosphatase SHP-1 acts as a negative regulator in endothelial superoxide production. In this study we investigated the influence of SH...