Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase

• Main Authors: Sonali Kurup (Author), Bradley McAllister (Author), Pavlina Liskova (Author), Trusha Mistry (Author), Anthony Fanizza (Author), Dan Stanford (Author), Jolanta Slawska (Author), Ulrich Keller (Author), Alexander Hoellein (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Simultaneous inhibition of multiple kinases has been suggested to provide synergistic effects on inhibition of tumour growth and resistance. This study describes the design, synthesis and evaluation of 18 compounds incorporating a pyrrolo[2,3-d]pyrimidine scaffold for dual inhibition of epidermal gr...