Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells

• Main Authors: Maritza P. Garrido (Author), Renato Salvatierra (Author), Manuel Valenzuela-Valderrama (Author), Christopher Vallejos (Author), Nicole Bruneau (Author), Andrea Hernández (Author), Margarita Vega (Author), Alberto Selman (Author), Andrew F. G. Quest (Author), Carmen Romero (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epithelial ovarian cancer (EOC) is a lethal gynaecological neoplasm characterized by rapid growth and angiogenesis. Nerve growth factor (NGF) and its high affinity receptor tropomyosin receptor kinase A (TRKA) contribute to EOC progression by increasing the expression of c-MYC, survivin and vascular...