Development and validation of a rapid and sensitive UHPLC-MS/MS method for the determination of paliperidone in beagle dog plasma

• Main Authors: Hongming Chen (Author), Longshan Zhao (Author), Guangjing Li (Author), Donglei Leng (Author), Panqin Ma (Author), Lijin Tong (Author), Tianhong Zhang (Author)
• Format: Book
• Published: Elsevier, 2014-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In order to evaluate the pharmacokinetic profile of paliperidone extended-release tablets in vivo, a simple and rapid ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for the determination of paliperidone in beagle dog plasma. Pal...