Synthesis and Evaluation of Antiproliferative Activity, Topoisomerase IIα Inhibition, DNA Binding and Non-Clinical Toxicity of New Acridine-Thiosemicarbazone Derivatives

• Main Authors: Gleyton Sousa (Author), Maria C. F. de Almeida (Author), Lucas L. Lócio (Author), Vanda L. dos Santos (Author), Daniel P. Bezerra (Author), Valdenizia R. Silva (Author), Sinara M. V. de Almeida (Author), Alice Simon (Author), Thiago da S. Honório (Author), Lucio M. Cabral (Author), Rosane N. Castro (Author), Ricardo O. de Moura (Author), Arthur E. Kümmerle (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we report the synthesis of twenty new acridine-thiosemicarbazone derivatives and their antiproliferative activities. Mechanisms of action such as the inhibition of topoisomerase IIα and the interaction with DNA have been studied for some of the most active derivatives by means of both...