Isoniazid causes heart looping disorder in zebrafish embryos by the induction of oxidative stress

• Main Authors: Jie Ni (Author), Hongye Wang (Author), Xiyi Wei (Author), Kangjie Shen (Author), Yeqin Sha (Author), Yuxiang Dong (Author), Yimei Shu (Author), Xiaojie Wan (Author), Jingwen Cheng (Author), Fang Wang (Author), Yihai Liu (Author)
• Format: Book
• Published: BMC, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The cardiotoxicity of isoniazid on zebrafish embryos and its underlying mechanism is unclear. Methods Here, we exposed zebrafish embryos at 4 h post-fertilization to different levels of isoniazid and recorded the morphology and number of malformed and dead embryos under the micro...