Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon

• Main Authors: Katrijn Broos (Author), Kevin Van der Jeught (Author), Janik Puttemans (Author), Cleo Goyvaerts (Author), Carlo Heirman (Author), Heleen Dewitte (Author), Rein Verbeke (Author), Ine Lentacker (Author), Kris Thielemans (Author), Karine Breckpot (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer vaccines based on mRNA are extensively studied. The fragile nature of mRNA has instigated research into carriers that can protect it from ribonucleases and as such enable its systemic use. However, carrier-mediated delivery of mRNA has been linked to production of type I interferon (IFN) that...