Potency, Safety, and Pharmacokinetic Profiles of Potential Inhibitors Targeting SARS-CoV-2 Main Protease

• Hlavní autoři: Hylemariam Mihiretie Mengist (Autor), Daniel Mekonnen (Autor), Ahmed Mohammed (Autor), Ronghua Shi (Autor), Tengchuan Jin (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Effective, safe, and pharmacokinetically suitable drugs are urgently needed to curb the ongoing COVID-19 pandemic. The main protease or 3C-like protease (Mpro or 3CLpro) of SARS-CoV-2 is considered an important target to formulate potent drugs corresponding to its crucial role in virus replication a...