Knock-out of CD73 delays the onset of HR-negative breast cancer by reprogramming lipid metabolism and is associated with increased tumor mutational burden

• Main Authors: Paweł Kamil Serafin (Author), Marta Popęda (Author), Kamila Bulak (Author), Agata Zwara (Author), Barbara Galikowska-Bogut (Author), Anna Przychodzka (Author), Adriana Mika (Author), Tomasz Śledziński (Author), Marcin Stanisławowski (Author), Kamila Jendernalik (Author), Marika Bolcewicz (Author), Wiktoria Laprus (Author), Grzegorz Stasiłojć (Author), Rafał Sądej (Author), Anna Żaczek (Author), Leszek Kalinowski (Author), Patrycja Koszałka (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: CD73 (ecto-5'-nucleotidase, NT5E), a cell-surface enzyme converting 5'-AMP to adenosine, is crucial for cancer progression. However, its role in the tumorigenesis process remains mostly obscure. We aimed to demonstrate CD73's role in breast cancer (BC) tumorigenesis through...