Enhanced immunogenic potential of cancer immunotherapy antibodies in human IgG1 transgenic mice
Clinical anti-drug-antibody (ADA) responses represent a substantial obstacle to the development of efficacious therapeutic antibodies. The enhanced ADA production against the idiotype (Id) often displayed by cancer immunotherapy antibodies (CitAbs) can lead to exposure loss and subsequently affect a...
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Taylor & Francis Group,
2022-12-01T00:00:00Z.
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