Item response theory in early phase clinical trials: Utilization of a reference model to analyze the Montgomery‐Åsberg Depression Rating Scale

Abstract In clinical trials, Montgomery‐Åsberg Depression Rating Scale (MADRS) questionnaire data are added up to total scores before analysis, assuming equal contribution of each separate question. Item Response Theory (IRT)‐based analysis avoids this by using individual question responses to deter...

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Bibliographic Details
Main Authors: Marije E. Otto (Author), Kirsten R. Bergmann (Author), Marieke L. deKam (Author), Kasper Recourt (Author), Gabriël E. Jacobs (Author), Michiel J. vanEsdonk (Author)
Format: Book
Published: Wiley, 2023-10-01T00:00:00Z.
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3rd Floor Main Library

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