A Double‐Blind, Phase I, Single Ascending Dose Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of BOS161721 in Healthy Subjects

A Double‐Blind, Phase I, Single Ascending Dose Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of BOS161721 in Healthy Subjects

The purpose of this study was to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of BOS161721, a humanized immunoglobulin G1 triple mutation (M252Y/S254T/T256E) monoclonal antibody that inhibits interleukin‐21 (IL‐21) bioactivity. This randomized, single‐cente...

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Main Authors: Azra Hussaini (Author), Rajat Mukherjee (Author), Dina M. Berdieva (Author), Christen Glogowski (Author), Richard Mountfield (Author), Peter T.C. Ho (Author)
Format: Book
Published: Wiley, 2020-03-01T00:00:00Z.
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