Evidence for Separate Involvement of Different μ-Opioid Receptor Subtypes in Itch and Analgesia Induced by Supraspinal Action of Opioids

• Main Authors: Tsugunobu Andoh (Author), Yuichi Yageta (Author), Mitsuhiro Konno (Author), Tomomi Yamaguchi-Miyamoto (Author), Hiroki Takahata (Author), Hiroshi Nojima (Author), Hideo Nemoto (Author), Yasushi Kuraishi (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The common adverse effect of centrally-injected μ-opioid receptor (μ-OR) agonists is pruritus. This study was conducted using mice to examine whether different subtypes of μ-OR would be responsible for pruritus and analgesia. Intracisternal injections of morphine and morphine-6β-glucronide (M6G), bu...