Identification, synthesis, and characterization of potential genotoxic impurities of sildenafil citrate drug substance

• Main Authors: P. Rajesh Reddy (Author), Sivanadh Musunuri (Author), D. Rama Sekhara Reddy (Author), V. Subrahmanyam Chittala (Author), V. N. S. Murthy P (Author), K. Krishnamohan (Author)
• פורמט: ספר
• יצא לאור: SpringerOpen, 2020-11-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract Background Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specifil phophodiesterase type 5 (PDE5). Sildenafil enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5, which is responsible for the degradation of cGMP in the corpus cavernosum....