Identification, synthesis, and characterization of potential genotoxic impurities of sildenafil citrate drug substance

• Asıl Yazarlar: P. Rajesh Reddy (Yazar), Sivanadh Musunuri (Yazar), D. Rama Sekhara Reddy (Yazar), V. Subrahmanyam Chittala (Yazar), V. N. S. Murthy P (Yazar), K. Krishnamohan (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: SpringerOpen, 2020-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Background Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specifil phophodiesterase type 5 (PDE5). Sildenafil enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5, which is responsible for the degradation of cGMP in the corpus cavernosum....